In 2011 WHO conditionally recommended the use of at least 36 months of isoniazid preventive therapy (IPT) (as a proxy for lifelong or continuous treatment) for people living with HIV in high TB-prevalence and transmission settings. The evidence of the benefits and harms of 36-month IPT compared to 6-mont...
The objective of this document is to provide technical recommendations on effective interventions for the prevention and treatment of HIV and other sexually transmitted infections (STIs) among sex workers and their clients. These include evidence-based recommendations following the GRADE methodology as w...
Research over the past decade has resulted in the development of two commercial interferongamma release assays (IGRAs), based on the principle that the T-cells of individuals who have acquired TB infection respond to re-stimulation with Mycobacterium tuberculosis-specific antigens by secreting interferon...
WHO guidelines for ART for HIV infection in adults and adolescents were originally published in 2002, and were revised in 2003 and 2006. New evidence has emerged on when to initiate ART, optimal ART regimens, the management of HIV coinfection with tuberculosis and chronic viral hepatitis, and the managem...
Malnutrition is the largest single underlying cause of death worldwide and is associated with over 1/3 of all childhood deaths. The objective of the document is to provide a summary of existing WHO information regarding the principles of identification and management of communicable diseases in malnouris...
The Manual is based on a public health approach to scaling-up HIV services in resource-constrained settings. Th is approach includes simple, standardized regimens and formularies; algorithmic clinical decision-making; standardized supervision and patient monitoring approaches; as well as integrated deliv...
